Plantar involvement correlates with obesity, pain and impaired mobility in epidermolysis bullosa simplex: a retrospective cohort study

Background Epidermolysis bullosa simplex (EBS) is the most common type of EB, a group rare genodermatoses. Affected individuals suffer from skin blistering and report high disease burden. In some EBS subtypes, plantar keratoderma (PK) has been described. Objectives This study investigated presence correlation PK with body mass index, pain mobility in EBS. Methods Individuals (n = 157) genetically characterized were included this retrospective cohort study, clinical data collected over 16 years (referral patients to largest German EB centre). Descriptive statistics mixed linear models used assess correlations. Results was found 75.8% beginning at mean age 4.3 years. Both focal diffuse observed, 60% adults localized severe preobese or obese, ˜30% reporting severely reduced mobility. The PK, especially correlated significantly local infections, obesity, requirement wheelchair. Conclusion Along treating fragility blistering, should be considered potential marker increased morbidity may represent target therapy development.